Supplements and minerals
DAO enzyme supplementsfor histamine intolerance symptom relief
Consider oral DAO supplements to help break down histamine and reduce related symptoms, though evidence is promising but not definitive.
- State
- Recommended
- Research
- Research limited: expert opinion
- Agreement
- 70 of 100
- Experts
- 3 experts
Updated 23 September 2026
““DAO” is an enzyme you can take with high histamine foods to help you break it down”
a registered dietitian · Source
What to do
Consider oral DAO supplements to help break down histamine and reduce related symptoms, though evidence is promising but not definitive. This entry applies for histamine intolerance symptom relief.
What the experts say
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a registered dietitianRecommends
“DAO is an enzyme you can take with high histamine foods to help break down histamine.”
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an endocrinology-trained performance coachConditional
“Supplemental DAO could be useful to degrade histamine and prevent histamine intolerance.”
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one of our sourcesConditional
“Oral DAO enzyme may reduce GI and skin symptoms related to histamine intolerance based on an open-label pilot study.”
Before you act. Entrain is a free knowledge resource. It brings together what named doctors, scientists and coaches teach publicly, with sources, so you can explore and discuss it with your own clinician. It does not diagnose, treat or prescribe, and it is not a substitute for medical care.